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黄守杰(Shou-Jie Huang)

教授级高级工程师

硕士生导师

Tel: 0592-2188393(O)

E-mail: huangshoujie@xmu.edu.cn

一、学习经历

2008厦门大学生物化学与分子生物学硕士

1999北京大学公共卫生学院预防医学学士

二、主要研究方向

疫苗临床试验、传染病流行病学

三、科研成果

2006年至今从事疫苗临床试验和传染病流行病学研究,在疫苗临床试验具有丰富的经验。作为主要研究成员共完成12项疫苗临床试验,包括戊肝疫苗系列临床试验6项,HPV疫苗系列临床试验6项。国家一类新药戊型肝炎疫苗和HPV16/18型双价疫苗均已获得新药证书并成功上市。主持或参与国家自然科学基金、国家传染病重大科技专项等10多个项目。已在NEJMLancetCMIVaccine等学术刊物发表论文50多篇。先后获得江苏省科学技术奖一等奖(2012年)、求是科技基金会杰出科技成就集体奖(2015年)等科研奖励。

1 代表性论文

  1. Xu-ya Yu#, Zhi-ping Chen#, Shen-yu Wang, Hui-rong Pan, Zhi-fang Wang, Qiu-fen Zhang, Ling-zhi Shen, Xiao-ping Zheng, Chuan-fu Yan, Mei Lu, Bo Chen, Ya Zheng, Jun Zhang, Hua-kun Lv*, Shou-jie Huang*. Safety and immunogenicity of hepatitis E vaccine in elderly people older than 65 years[J].Vaccine, 2019, 37(32): 4581-4586.

  2. You-Lin Qiao#*, Ting Wu#, Rong-Cheng Li#, Yue-Mei Hu#, Li-Hui Wei#, Chang-Gui Li#, Wen Chen#, Shou-Jie Huang, Fang-Hui Zhao, Ming-Qiang Li, Qin-Jing Pan, Xun Zhang, Qing Li, Ying Hong, Chao Zhao, Wen-Hua Zhang, Yan-Ping Li, Kai Chu, Mei Li, Yun-Fei Jiang, Juan Li, Hui Zhao, Zhi-Jie Lin, Xue-Lian Cui, Wen-Yu Liu, Cai-Hong Li, Dong-Ping Guo, Li-Dong Ke, Xin Wu, Jie Tang, Guo-Qi Gao, Ba-Yi Li, Bin Zhao, Feng-Xian Zheng, Cui-Hong Dai, Meng Guo, Jun Zhao, Ying-Ying Su, Jun-Zhi Wang, Feng-Cai Zhu, Shao-Wei Li, Hui-Rong Pan, Yi-Min Li, Jun Zhang*, Ning-Shao Xia*. Efficacy, Safety, and Immunogenicity of an Escherichia coli-Produced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial[J]. Journal of the National Cancer Institute, 2020, 112(2): 145-153.

  3. Zhiping Chen#, Shuzhen Lin#, Jiafu Duan#, Yan Luo, Shenyu Wang, Zhengkai Gan, Huaiming Yi, Ting Wu, Shoujie Huang*, Qiufen Zhang*, Huakun Lv*. Immunogenicity and safety of an accelerated hepatitis E vaccination schedule in healthy adults: a randomized, controlled, open-label, phase IV trial[J]. Clinical Microbiology and Infection, 2019, 25(9): 1133-1139.

  4. 余小娟, 潘莉莉, 苏迎盈, 吴婷, 黄守杰*. 乙戊型肝炎病毒重叠感染的研究进展[J]. 病毒学报, 2019, 35(2): 318-322.

  5. 郑亚, 李亚飞, 姚星妹, 吴婷, 黄守杰, 张军, 夏宁邵. 戊型肝炎疫苗临床研究进展[J]. 病毒学报, 2018, 34(6): 951-958.

  6. H. JIANG#S. HUANG#Y. ZHAO#Y. WANGC. YANGJ. CAIZ. WANGJ. ZHANGX. ZHANG*H. JIN. Disease burden of hepatitis E in a rural population in China: a community-based survey [J]. Epidemiol. Infect., 2017, 145(5): 908-913.

  7. Y. Liu#, S. Huang#, H. Jiang, J. Xiong, Y. Wang, M. Ou, J. Cai, C. Yang, Z. Wang, S. Ge*, N. Xia. The prevalence of latent tuberculosis infection in rural Jiangsu, China [J]. Public Health, 2017, 146: 39-45.

  8. Yingying Su#, Shoujie Huang#, Meng Guo, Jun Zhao, Huan Yu, Wengang He, Hanmin Jiang, Yijun Wang, Xuefeng Zhang, Jiaping Cai, Changlin Yang, Zhongze Wang, Fengcai Zhu,  Ting Wu*, Jun Zhang*, NingShao Xia. Persistence of antibodies acquired by natural hepatitis E virus infection and the effects of vaccination [J]. Clinical Microbiology and Infection, 2017, 23 (5): 336.e1-336.e4.

  9. 姜汉民,王一军,张雪峰,王忠泽,杨昌林,蔡加平,闫强,吴婷,张军,朱凤才,夏宁邵,黄守杰*. 江苏省东台市农村地区散发戊型病毒性肝炎流行病学特征分析[J]. 中国人兽共患病学报, 2016, 32(1): 95-98.

  10. Jun Zhang#*, Xue-Feng Zhang#, Shou-Jie Huang, Ting Wu, Yue-Mei Hu, Zhong-Ze Wang, Hua Wang, Han-Min Jiang, Yi-Jun Wang, Qiang Yan, Meng Guo, Xiao-Hui Liu, Jing-Xin Li, Chang-Lin Yang, Quan Tang, Ren-Jie Jiang, Hui-Rong Pan, Yi-Min Li, J. Wai-Kuo Shih, Mun-Hon Ng, Feng-Cai Zhu*, Ning-Shao Xia*. Long-term efficacy of a hepatitis E vaccine [J]. New England Journal of Medicine, 2015, 372(10): 914-922.

  11. Feng-Cai Zhu#, Shou-Jie Huang#, Ting Wu, Xue-Feng Zhang, Zhong-Ze Wang, Xing Ai, Qiang Yan, Chang-Lin Yang, Jia-Ping Cai, Han-Min Jiang, Yi-Jun Wang, Mun-Hon Ng, Jun Zhang*, Ning-Shao Xia. Epidemiology of Zoonotic Hepatitis E: A Community-Based Surveillance Study in a Rural Population in China [J]. PloS one, 2014, 9(1): e87154.

  12. Shou-Jie Huang, Xiao-Hui Liu, Jun Zhang, Mun-Hon Ng. Protective immunity against HEV [J]. Current opinion in virology, 2014, 5(1): 1-6.

  13. Yuemei Hu#, Shou-Jie Huang#, Kai Chu, Ting Wu, Zhong-Ze Wang, Chang-Lin Yang, Jia-Ping Cai, Han-Min Jiang, Yi-Jun Wang, Meng Guo, Xiao-Hui Liu, Hong-Jiang Huang, Feng-Cai Zhu, Jun Zhang*, Ning-Shao Xia. Safety of an Escherichia coli-expressed bivalent human papillomavirus (types 16 and 18) L1 virus-like particle vaccine: An open-label phase I clinical trial [J]. Human vaccines & immunotherapeutics, 2014, 10(2): 469-475.

  14. J. Zhang#, X.-F. Zhang#, C. Zhou, Z.-Z. Wang, S.-J. Huang, X. Yao, Z.-L. Liang, T. Wu, J.-X. Li, Q. Yan, C.-L. Yang, H.-M. Jiang, H.-J. Huang, Y.-L. Xian, J. W.-K. Shih, M.-H. Ng, Y.-M. Li, J.-Z. Wang*, F.-C. Zhu*, N.-S. Xia*. Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity [J]. Clinical Microbiology and Infection, 2014, 20(6): O397-O405.

  15. Ting Wu*, Shou-Jie Huang, Feng-Cai Zhu, Xue-Feng Zhang, Xing Ai, Qiang Yan, Zhong-Ze Wang, Chang-Lin Yang, Han-Min Jiang, Xiao-Hui Liu, Meng Guo, Hai-Lian Du, Mun-Hon Ng, Jun Zhang, Ningshao Xia. Immunogenicity and safety of hepatitis E vaccine in healthy hepatitis B surface antigen positive adults [J]. Human Vaccines & Immunotherapeutics, 2013, 9(11): 2474-2479.

  16. Ting Wu, Feng-Cai Zhu, Shou-Jie Huang, Xue-Feng Zhang, Zhong-Ze Wang, Jun Zhang, Ning-Shao Xia. Safety of hepatitis E vaccine for pregnant women: a preliminary analysis [J]. Hepatology, 2012, 55(6): 2038-2038.

  17. 黄守杰, 张雪峰, 黄鸿江, 姜汉民, 王一军, 蔡加平, 杨昌林, 王忠泽, 吴婷, 朱凤才, 张军*, 夏宁邵. 散发型戊型肝炎与急性乙肝临床特征比较[J]. 中国人兽共患病学报, 2011, 27(1): 11-13.

  18. Shoujie Huang#, Xuefeng Zhang#, Hanmin Jiang, Qiang Yan, Xing Ai, Yijun Wang, Jiaping Cai, Lang Jiang, Ting Wu, Zhongze Wang, Li Guan, J. Wai Kuo Shih, Mun-Hon Ng, Fengcai Zhu, Jun Zhang*, Ningshao Xia. Profile of acute infectious markers in sporadic hepatitis E[J]. PloS one, 2010, 5(10): e13560.

  19. Feng-Cai Zhu#, Jun Zhang#, Xue-Feng Zhang, Cheng Zhou, Zhong-Ze Wang, Shou-Jie Huang, Hua Wang, Chang-Lin Yang, Han-Min Jiang, Jia-Ping Cai, Yi-Jun Wang, Xing Ai, Yue-Mei Hu, Quan Tang, Xin Yao, Qiang Yan, Yang-Ling Xian, Ting Wu, Yi-Min Li, Ji Miao, Mun-Hon Ng, James Wai-Kuo Shih, Ning-Shao Xia*. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial [J]. Lancet, 2010, 376(9744): 895-902.

2 课题

(1) 国家科技重大专项-重大新药创制,重组人乳头瘤病毒16/18型双价疫苗的III期临床研究和产业化,参加

(2)国家自然科学基金委员会面上项目,固定人群10年间戊型肝炎病毒分子进化特征研究,主持

(3) 国家科技重大专项-重大新药创制,重组戊型肝炎疫苗IV期临床试验,参加

四、获奖和荣誉

  1. 2019年获得榴莲官网自直接进入养生堂奖教金;

  2. 2017年获得榴莲官网自直接进入四川美特奖教金;

  3. 2015年获求是科技基金会杰出科技成就集体奖;

  4. 2014年获得厦门大学校庆中国银行教科辅奖教金;

  5. 2012年获得榴莲官网自直接进入养生堂奖教金;

  6. 2012年获得江苏省科学技术奖一等奖;